RPR may be a useful measurement for the assessment of disease activity in SLE patients. RPR level was correlated with clinical disease activity in SLE, and its value was normalized after treatment. According to the receiver-operating characteristic (ROC) curve, the optimal cut-off value for predicting SLE using RPR was 0.073, and the area under ROC curve was 0.817. 001) and erythrocyte sedimentation rate ( r = 0.313, P =. The RPR level was found to be positively correlated with SLEDAI ( r = 0.368, P <. 001), whereas mean platelet volume was decreased ( P <. The PLR and RPR values of SLE patients were significantly higher compared with the controls (both P <. A subgroup follow-up analysis of 93 patients was conducted to explore the effect of SLE-related glucocorticoid therapy. Correlations between RPR and disease activity were then analyzed. Group 1 included patients with SLEDAI score ≤9 (mild disease activity group) and group 2 with SLEDAI >9 (severe disease activity group). We divided the patients into 2 groups using the SLE Disease Activity Index (SLEDAI) 2000. This study enrolled 105 SLE patients and 105 healthy subjects. Therefore, the aim of this study was to investigate the association between RPR levels and disease activity in SLE. The work cannot be changed in any way or used commercially without permission from the journal.Īlthough different clinical and experimental parameters have been used to estimate disease activity in systemic lupus erythematosus (SLE) patients, the relationship between red blood cell distribution width-to-platelet ratio (RPR) and disease activity in SLE has not been previously illuminated. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The authors have no conflicts of interest to disclose. Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.Ĭorrespondence: Xuejie Chen, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China (e-mail: ).Ībbreviations: anti-dsDNA = antidouble-stranded antibody, CRP = C-reactive protein, ESR = erythrocyte sedimentation rate, MPV = mean platelet volume, NLR = neutrophil-to-lymphocyte ratio, PLR = platelet-to-lymphocyte ratio, RDW = red blood cell distribution width, ROC = receiver-operating characteristic, RPR = red blood cell distribution width-to-platelet ratio, SLE = systemic lupus erythematosus, SLEDAI = Systemic Lupus Erythematosus Disease Activity Index.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |